Amyloid Deposition and Angiitis: Spectrum of Radiologic Manifestations

E. Portela de Oliveira, V. Yogendrakumar, N. Zakhari, T. Nguyen, and C. Torres

View Article on Neurographics Website

Date of Activity Release: March 26, 2019
Date of Activity Expiration: March 26, 2022

Target Audience:
Intended for neuroradiologists and neuroradiology trainees with varying degrees of experience.

Learning Objective:
Assess the main imaging findings of the cerebral amyloid angiopathy forms, including the inflammatory form, and describe the clinical-radiologic criteria for the diagnosis.

Cerebral amyloid angiopathy is defined as cerebrovascular amyloid deposition and is classified according to the amyloid protein involved. Cerebral amyloid angiopathy with B-amyloid protein deposition in the sporadic form of presentation is by far the most common form of cerebral amyloid angiopathy seen in elderly individuals who are asymptomatic, as well as in patients with acute intracranial hemorrhage and Alzheimer disease. -amyloid– type cerebral amyloid angiopathy has a broad spectrum of radiologic manifestations and a high prevalence among the elderly population. Neuroimaging plays an important role in the diagnosis and management of the common clinical presentations of cerebral amyloid angiopathy, for example, the classic lobar intracerebral hemorrhage, and is also useful in detecting clinically silent microbleeds and microinfarctions. -amyloid–type cerebral amyloid angiopathy can present with associated inflammation, an infrequent form called cerebral amyloid angiopathy–related inflammation, in which patients present with acute cognitive decline. Cerebral amyloid angiopathy–related inflammation can demonstrate asymmetric white matter changes and leptomeningeal enhancement, and its recognition is critical to establish early treatment, given that these changes are reversible and respond well to steroids and other immunosuppressant therapies.

Commercial Support
No commercial support was received for this activity.

Credit Designation Statement

The American Society of Neuroradiology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The American Society of Neuroradiology designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Method of Physician Participation:
Each participant will review the corresponding Neurographics article located at Upon completion, each physician will complete and pass a post-test with a score of at least 80% to receive a CME certificate.

All individuals in control of content have disclosed the following relevant financial relationships. All of these relationships were treated as a conflict of interest, and have been resolved (C7 SCS 6.1-6.2, 6.5)

T. Nguyen - UNRELATED: Grants/ grants pending: GE Healthcare, Comments: Research grant*.

*money paid to institution





Barton Branstetter 

Editor in Chief

None, N/A

Adam Flanders

Deputy Editor

Royalties, Lippincott Williams and Wilkins

Robert Quencer 

Consulting Editor

None, N/A

Mark Mullins

Associate Editor

Non-remunerative position, AUR6

Meng Law

Associate Editor

Stockholder, Clinical Imaging

Edward Escott

Associate Editor

Grant, Atherysys, Inc.; Royalties, Thieme Medical Publishers

Scott Faro

Associate Editor

None, N/A

Tina Young Poussaint

Associate Editor

None, N/A

Dheeraj Ghandi

Associate Editor

Grant, Arstasis, Axera Inc.; Consultant, Covidien, EV3

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