Neurographics

Imaging Features in Cerebral Amyloid Angiopathy

L. Koren, A. Hilario, E. Salvador, P. Martín, F. Ballenilla, J.M. Milla´n, A. Hernandez-Laín, and A. Ramos

View Article on Neurographics Website

Date of Activity Release: Aug. 1, 2017
Date of Activity Expiration: Aug. 1, 2020

Target Audience:
Intended for neuroradiologists and neuroradiology trainees with varying degrees of experience.

Learning Objectives:
To describe MR imaging findings of cerebral amyloid angiopathy related disorders and to define the diagnostic criteria that allows a presumptive diagnosis without the need for a brain biopsy.

Abstract
Cerebral amyloid angiopathy is a disorder characterized by deposition of amyloid peptide in the media and adventitia of leptomeningeal and cortical vessels of the central nervous system. Amyloid deposition leads to vessel fragility and rupture, so, even if cerebral amyloid angiopathy can be asymptomatic, intracerebral hemorrhage is the most common clinical manifestation. A definitive diagnosis requires a brain biopsy; however, advances in diagnostic procedures, particularly neuroimaging, have enabled us to establish a diagnosis based on standardized clinical and radiologic criteria. In this article, we aimed to present a systematic review of cerebral amyloid angiopathy related disorders with regard to their epidemiology, pathophysiology, clinical features, neuroimaging biomarkers, diagnosis criteria, and treatment. We also focused attention on a rare, lesser-known form of inflammatory angiopathy attributed to amyloid: cerebral amyloid angiopathy associated with inflammatory process.

Commercial Support
No commercial support was received for this activity.

Credit Designation Statement

The American Society of Neuroradiology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The American Society of Neuroradiology designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Method of Physician Participation:
Each participant will review the corresponding Neurographics article located at www.neurographics.org. Upon completion, each physician will complete and pass a post-test with a score of at least 80% to receive a CME certificate.

Disclosures:
All individuals in control of content have disclosed the following relevant financial relationships. All of these relationships were treated as a conflict of interest, and have been resolved (C7 SCS 6.1-6.2, 6.5)

Authors:
Authors have no relevant financial relationships.

Planners:

Name

Role

Relationship/Interest

Barton Branstetter 

Editor in Chief

None, N/A

Adam Flanders

Deputy Editor

Royalties, Lippincott Williams and Wilkins

Robert Quencer 

Consulting Editor

None, N/A

Mark Mullins

Associate Editor

Non-remunerative position, AUR6

Meng Law

Associate Editor

Stockholder, Clinical Imaging

Michele Johnson

Associate Editor

Consultant, Boston Scientific, Inc.

Edward Escott

Associate Editor

Grant, Atherysys, Inc.; Royalties, Thieme Medical Publishers

Scott Faro

Associate Editor

None, N/A

Tina Young Poussaint

Associate Editor

None, N/A

Dheeraj Ghandi

Associate Editor

Grant, Arstasis, Axera Inc.; Consultant, Covidien, EV3

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