Neurographics

Diffusion Tensor Imaging and Fiber Tractography of Pediatric Posterior Fossa Malformations

A. Meoded; T. Bosemani; E. Boltshauser; I. Scheer; T.A.G.M. Huisman; A. Poretti

View Article on Neurographics Website

Date of Activity Release: Aug. 1, 2017
Date of Activity Expiration: Aug. 1, 2020

Target Audience:
Intended for neuroradiologists and neuroradiology trainees with varying degrees of experience.

Learning Objectives:
To recognize the utility of diffusion tensor imaging and fiber tractography to study malformations of the posterior fossa and highlight the additional information that diffusion tensor imaging and fiber tractography may provide compared with conventional MR imaging sequences.

Abstract
Diffusion tensor imaging (DTI) is an advanced MR imaging technique that provides noninvasive qualitative and quantitative information about the white matter microarchitecture. DTI and fiber tractography have been increasingly used in the past decade to investigate the microstructural neuroarchitecture of posterior fossa malformations. This article aimed to review DTI and fiber tractography findings in several posterior fossa malformations, and highlighted the added value of DTI and fiber tractography compared with conventional MR imaging. DTI and fiber tractography may provide information that is helpful to better understand the pathogenesis of selected posterior fossa malformations. In addition, DTI may elucidate the anatomic role of the cerebellum for neurocognitive functions in children with posterior fossa malformations and DTI scalars of the cerebellar, and brain stem white matter tracts may serve as a predictive biomarker for cognitive outcome. Finally, quantitative DTI analysis of cerebellar and brain stem white matter tracts may help to select candidates for therapeutic interventions and may enable monitoring of the therapy response.
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Commercial Support
No commercial support was received for this activity.

Credit Designation Statement

The American Society of Neuroradiology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The American Society of Neuroradiology designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Method of Physician Participation:
Each participant will review the corresponding Neurographics article located at www.neurographics.org. Upon completion, each physician will complete and pass a post-test with a score of at least 80% to receive a CME certificate.

Disclosures:
All individuals in control of content have disclosed the following relevant financial relationships. All of these relationships were treated as a conflict of interest, and have been resolved (C7 SCS 6.1-6.2, 6.5)

Authors:
Authors have no relevant financial relationships.

Planners:

Name

Role

Relationship/Interest

Barton Branstetter 

Editor in Chief

None, N/A

Adam Flanders

Deputy Editor

Royalties, Lippincott Williams and Wilkins

Robert Quencer 

Consulting Editor

None, N/A

Mark Mullins

Associate Editor

Non-remunerative position, AUR6

Meng Law

Associate Editor

Stockholder, Clinical Imaging

Michele Johnson

Associate Editor

Consultant, Boston Scientific, Inc.

Edward Escott

Associate Editor

Grant, Atherysys, Inc.; Royalties, Thieme Medical Publishers

Scott Faro

Associate Editor

None, N/A

Tina Young Poussaint

Associate Editor

None, N/A

Dheeraj Ghandi

Associate Editor

Grant, Arstasis, Axera Inc.; Consultant, Covidien, EV3

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