Pearls and Pitfalls of DaT-SPECT Imaging in Neurodegenerative Disorders: What the Radiologists and Clinicians Need to Know

Chaudhry, A.A.; Gul, M.; Gupta, R.; Chaudhry, A.; Sheikh, M.; Peyster, R.; Matthews, R

View Article on Neurographics Website

Date of Activity Release: Aug. 1, 2016
Date of Activity Expiration: Aug. 1, 2019

Target Audience:
Intended for neuroradiologists and neuroradiology trainees with varying degrees of experience.

Learning Objectives:
Identify normal and abnormal patterns in dopamine transporter SPECT imaging that result from various movement disorders and develop familiarity with common pitfalls that may result in false-positive examination.

With the growing population of the elderly in the United States, the incidence and prevalence of neurodegenerative movement disorders is increasing. Because most of the conventional radiologic examinations fail to detect the early stage of these processes, various clinical diagnostic criteria have been developed to detect these conditions. Fortunately, with the recent advancement of diagnostic imaging, several new techniques have been developed that can diagnose these conditions at a much earlier stage, which allows for institution of therapy that can delay disease progression. In this review article, we aimed to review the anatomy, pathophysiology, and imaging findings (including SPECT imaging, CT, and MR imaging) of various movement disorders (eg, Parkinson disease, progressive supranuclear palsy), and discuss respective differential diagnoses, with emphasis on key discriminant features that allow for accurate diagnosis. In addition, we discussed pearls and pitfalls of SPECT imaging and reviewed and highlighted key points, which can help in avoiding these pitfalls.

Commercial Support
No commercial support was received for this activity.

Credit Designation Statement

The American Society of Neuroradiology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The American Society of Neuroradiology designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Method of Physician Participation:
Each participant will review the corresponding Neurographics article located at Upon completion, each physician will complete and pass a post-test with a score of at least 80% to receive a CME certificate.

All individuals in control of content have disclosed the following relevant financial relationships. All of these relationships were treated as a conflict of interest, and have been resolved (C7 SCS 6.1-6.2, 6.5)

Authors have no relevant financial relationships.





Barton Branstetter 

Editor in Chief

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Adam Flanders

Deputy Editor

Royalties, Lippincott Williams and Wilkins

Robert Quencer 

Consulting Editor

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Associate Editor

Non-remunerative position, AUR6

Meng Law

Associate Editor

Stockholder, Clinical Imaging

Michele Johnson

Associate Editor

Consultant, Boston Scientific, Inc.

Edward Escott

Associate Editor

Grant, Atherysys, Inc.; Royalties, Thieme Medical Publishers

Scott Faro

Associate Editor

None, N/A

Tina Young Poussaint

Associate Editor

None, N/A

Dheeraj Ghandi

Associate Editor

Grant, Arstasis, Axera Inc.; Consultant, Covidien, EV3

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